Endocrine Pharmacotherapy: Standardized Tongkat Ali (Eurycoma Longifolia) on Free Testosterone & SHBG
Clinical trials in hypogonadal and stressed men demonstrate that standardized Eurycoma longifolia root extract (LJ100®) significantly reduces Sex Hormone-Binding Globulin (SHBG) and elevates free testosterone (+37% to +46%) while lowering serum cortisol.
Key Clinical Takeaways & Systematic Review Summary
Clinical trials in hypogonadal and stressed men demonstrate that standardized Eurycoma longifolia root extract (LJ100®) significantly reduces Sex Hormone-Binding Globulin (SHBG) and elevates free testosterone (+37% to +46%) while lowering serum cortisol.
- Evidence Classification: Rigorously graded under standardized Cochrane & GRADE systematic review protocols.
- Literature Benchmark Dosage: 400 mg daily.
- Pharmacokinetic Timing: Morning administration with food; many protocols recommend 5 days on, 2 days off cycling..
- Active Primary PubMed Reference: PMID 23754792 (Journal of the International Society of Sports Nutrition).
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