---
title: "Urolithin A JAMA Trial: Mitophagy Activation, Muscle Endurance & hs-CRP Reduction (ENERGIZE JAMA Audit) | Nutrition Research Labs"
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description: "Clinical audit of ENERGIZE JAMA (PMID: 35584623, 66 older adults (65-90 years old)): Significant improvement in muscle endurance (number of contractions until f"
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> **Canonical Source:** [https://nutritionresearchlabs.com/studies/urolithin-a-mitophagy-vo2max-muscle-endurance-rct](https://nutritionresearchlabs.com/studies/urolithin-a-mitophagy-vo2max-muscle-endurance-rct)
>
> *Clinical audit of ENERGIZE JAMA (PMID: 35584623, 66 older adults (65-90 years old)): Significant improvement in muscle endurance (number of contractions until f*

## Media Hype vs. Absolute Clinical Reality (Information Gain Audit)

- **Viral Headline Claim:**
- **True Placebo-Adjusted Absolute Outcome:** Significant improvement in muscle endurance (number of contractions until fatigue) in hand and leg muscles (+12.0% in first dorsal interosseous), alongside significant drops in plasma acylcarnitines and hs-CRP.
- **Relative vs. Absolute Statistical Breakdown:** Only ~30-40% of the human population possesses the gut microbiome taxonomy (such as Gordonibacter urolithinfaciens) required to convert dietary ellagitannins into active Urolithin A, validating synthetic pure bioidentical administration.
- **Funding & Sponsor Audit:** Amazentis SA (EPFL Spin-off) (Industry Sponsored (Audited))
- **Human Equivalent Dosing Protocol:** 1000mg oral softgels or powder taken once daily in the morning with a meal.

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