---
title: "Retatrutide NEJM Trial: 24.2% Weight Loss & 86% Liver Fat Resolution via Triple Agonism (TRIUMPH Phase 2 Audit) | Nutrition Research Labs"
source_url: "https://nutritionresearchlabs.com/studies/retatrutide-phase-2-nejm-24-percent-weight-loss-liver-fat-study"
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description: "Clinical audit of TRIUMPH Phase 2 (PMID: 37366315, 338 adults with BMI >=30 or >=27 with weight-related comorbidity): At 48 weeks, retatrutide 12mg achieved a l"
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> **Canonical Source:** [https://nutritionresearchlabs.com/studies/retatrutide-phase-2-nejm-24-percent-weight-loss-liver-fat-study](https://nutritionresearchlabs.com/studies/retatrutide-phase-2-nejm-24-percent-weight-loss-liver-fat-study)
>
> *Clinical audit of TRIUMPH Phase 2 (PMID: 37366315, 338 adults with BMI >=30 or >=27 with weight-related comorbidity): At 48 weeks, retatrutide 12mg achieved a l*

## Media Hype vs. Absolute Clinical Reality (Information Gain Audit)

- **Viral Headline Claim:**
- **True Placebo-Adjusted Absolute Outcome:** At 48 weeks, retatrutide 12mg achieved a least-squares mean weight change of -24.2% (-26.2 kg) versus -2.1% (-2.4 kg) with placebo. In the MASH substudy, 86% of patients normalized liver fat (
- **Relative vs. Absolute Statistical Breakdown:** While the 24.2% absolute weight reduction is the largest ever recorded in a 48-week pharmacological trial, weight loss had not plateaued at week 48. Dose-dependent increases in resting heart rate (peak +4.7 bpm) were observed, requiring cardiovascular outcome trial surveillance in Phase 3.
- **Funding & Sponsor Audit:** Eli Lilly and Company (Industry Sponsored (Audited))
- **Human Equivalent Dosing Protocol:** Once-weekly subcutaneous injection with step-wise monthly titration: 2mg -> 4mg -> 8mg -> 12mg target maintenance dose.

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