---
title: "Multicenter Human NMN Trial: NAD+ Blood Levels & 6-Minute Walking Endurance (Multicenter Human NMN 2022 Audit) | Nutrition Research Labs"
source_url: "https://nutritionresearchlabs.com/studies/nmn-human-insulin-sensitivity-nad-blood-elevation-rct"
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description: "Clinical audit of Multicenter Human NMN 2022 (PMID: 36481744, 80 middle-aged healthy adults (40-65 years old)): Blood NAD+ concentrations doubled (+113% at 600m"
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> **Canonical Source:** [https://nutritionresearchlabs.com/studies/nmn-human-insulin-sensitivity-nad-blood-elevation-rct](https://nutritionresearchlabs.com/studies/nmn-human-insulin-sensitivity-nad-blood-elevation-rct)
>
> *Clinical audit of Multicenter Human NMN 2022 (PMID: 36481744, 80 middle-aged healthy adults (40-65 years old)): Blood NAD+ concentrations doubled (+113% at 600m*

## Media Hype vs. Absolute Clinical Reality (Information Gain Audit)

- **Viral Headline Claim:**
- **True Placebo-Adjusted Absolute Outcome:** Blood NAD+ concentrations doubled (+113% at 600mg and +121% at 900mg) compared to baseline. Six-minute walking distance increased significantly by +48 meters vs placebo.
- **Relative vs. Absolute Statistical Breakdown:** While blood NAD+ elevated dramatically in an unmistakable dose-dependent fashion, the 600mg and 900mg groups showed virtually identical clinical walking endurance improvements, demonstrating a saturation ceiling at 600mg/day in healthy adults.
- **Funding & Sponsor Audit:** Aba Chemicals & Metro International Biotech (Industry Sponsored (Audited))
- **Human Equivalent Dosing Protocol:** 600mg orally once daily in the morning on an empty stomach or with a light polyphenol-rich meal.

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