---
title: "Baylor GlyNAC Randomized Trial: Intracellular Glutathione, HOMA-IR & Mitochondrial Oxidation (Baylor GlyNAC RCT Audit) | Nutrition Research Labs"
source_url: "https://nutritionresearchlabs.com/studies/glynac-glutathione-aging-hallmarks-baylor-rct"
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description: "Clinical audit of Baylor GlyNAC RCT (PMID: 35975308, 24 older adults (61-80y) vs 12 matched young controls (21-30y)): Red blood cell glutathione increased +121%"
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> **Canonical Source:** [https://nutritionresearchlabs.com/studies/glynac-glutathione-aging-hallmarks-baylor-rct](https://nutritionresearchlabs.com/studies/glynac-glutathione-aging-hallmarks-baylor-rct)
>
> *Clinical audit of Baylor GlyNAC RCT (PMID: 35975308, 24 older adults (61-80y) vs 12 matched young controls (21-30y)): Red blood cell glutathione increased +121%*

## Media Hype vs. Absolute Clinical Reality (Information Gain Audit)

- **Viral Headline Claim:**
- **True Placebo-Adjusted Absolute Outcome:** Red blood cell glutathione increased +121%, plasma malondialdehyde (lipid peroxidation) fell -72%, IL-6 decreased -78%, fasting insulin dropped -64%, and 6-minute gait speed improved +12%.
- **Relative vs. Absolute Statistical Breakdown:** Glycine and NAC provide the dual rate-limiting precursors for intracellular de novo glutathione synthesis. When supplemented together at 100 mg/kg each, they restore the catalytic synthesis loop without negative feedback inhibition seen with oral glutathione.
- **Funding & Sponsor Audit:** National Institutes of Health (NIH) / National Institute on Aging (NIA) (Independent Academic / NIH)
- **Human Equivalent Dosing Protocol:** 100 mg/kg/day of Glycine PLUS 100 mg/kg/day of N-Acetylcysteine, divided into two equal doses with meals.

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