---
title: "Single High-Dose Creatine (0.35g/kg) Reverses Sleep Deprivation Cognitive Fatigue (BrainATP-Sleep Audit) | Nutrition Research Labs"
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description: "Clinical audit of BrainATP-Sleep (PMID: 38418482, 15 healthy adults undergoing 24 hours of total sleep deprivation): A single allometric dose of 0.35g/kg creati"
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> **Canonical Source:** [https://nutritionresearchlabs.com/studies/creatine-sleep-deprivation-cognitive-brain-atp-study](https://nutritionresearchlabs.com/studies/creatine-sleep-deprivation-cognitive-brain-atp-study)
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> *Clinical audit of BrainATP-Sleep (PMID: 38418482, 15 healthy adults undergoing 24 hours of total sleep deprivation): A single allometric dose of 0.35g/kg creati*

## Media Hype vs. Absolute Clinical Reality (Information Gain Audit)

- **Viral Headline Claim:**
- **True Placebo-Adjusted Absolute Outcome:** A single allometric dose of 0.35g/kg creatine monohydrate elevated cerebral phosphocreatine (PCr/Pi ratio) and prevented sleep-loss-induced deterioration in executive function, working memory, and cognitive processing speed.
- **Relative vs. Absolute Statistical Breakdown:** Creatine does not eliminate systemic sleep debt, restorative slow-wave delta sleep requirements, or adenosine clearance. It biochemically buffers acute prefrontal cortex phosphocreatine depletion, temporarily preserving cellular bioenergetics during severe metabolic stress.
- **Funding & Sponsor Audit:** Forschungszentrum Jülich & German Research Foundation (DFG) (Independent Academic / NIH)
- **Human Equivalent Dosing Protocol:** Single acute allometric oral bolus of 0.35g/kg dissolved in 500mL fluid taken at the onset of nocturnal sleep deprivation.

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