---
title: "HTD1801 Berberine Ursodeoxycholate Phase 2 Trial in MASH & Type 2 Diabetes (HTD1801 Phase 2a Audit) | Nutrition Research Labs"
source_url: "https://nutritionresearchlabs.com/studies/berberine-ursodeoxycholate-htd1801-mash-fatty-liver-trial"
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description: "Clinical audit of HTD1801 Phase 2a (PMID: 40258699, 100 patients with biopsy-proven MASH and diabetes/prediabetes): Absolute liver fat content measured by MRI-P"
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> **Canonical Source:** [https://nutritionresearchlabs.com/studies/berberine-ursodeoxycholate-htd1801-mash-fatty-liver-trial](https://nutritionresearchlabs.com/studies/berberine-ursodeoxycholate-htd1801-mash-fatty-liver-trial)
>
> *Clinical audit of HTD1801 Phase 2a (PMID: 40258699, 100 patients with biopsy-proven MASH and diabetes/prediabetes): Absolute liver fat content measured by MRI-P*

## Media Hype vs. Absolute Clinical Reality (Information Gain Audit)

- **Viral Headline Claim:**
- **True Placebo-Adjusted Absolute Outcome:** Absolute liver fat content measured by MRI-PDFF decreased by -4.8% in the 1000mg BID group versus -1.6% with placebo (p = 0.011), alongside significant reductions in ALT (-24.3 U/L) and HbA1c (-0.6%).
- **Relative vs. Absolute Statistical Breakdown:** Synthetic ionic salt bonding berberine with ursodeoxycholic acid overcomes natural berberine poor oral bioavailability (<5%), delivering high portal vein hepatic concentrations without massive gut distress.
- **Funding & Sponsor Audit:** HighTide Therapeutics (Industry Sponsored (Audited))
- **Human Equivalent Dosing Protocol:** 1000mg orally twice daily taken with breakfast and dinner.

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