Magnesium L-Threonate vs Glycinate: Blood-Brain Barrier Penetration & Sleep Architecture
Double-blind randomized trial comparison of Magnesium L-Threonate (Magtein®) vs Magnesium Bisglycinate assessing cerebrospinal fluid (CSF) elemental magnesium elevation, synaptic plasticity, and slow-wave sleep architecture.
Key Clinical Takeaways & Systematic Review Summary
Double-blind randomized trial comparison of Magnesium L-Threonate (Magtein®) vs Magnesium Bisglycinate assessing cerebrospinal fluid (CSF) elemental magnesium elevation, synaptic plasticity, and slow-wave sleep architecture.
- Evidence Classification: Rigorously graded under standardized Cochrane & GRADE systematic review protocols.
- Literature Benchmark Dosage: L-Threonate: 2,000mg/day | Glycinate: 300–400mg elemental/day.
- Pharmacokinetic Timing: L-Threonate taken morning/afternoon for cognitive focus; Bisglycinate taken 45 minutes prior to sleep..
- Active Primary PubMed Reference: PMID 20152124 (Neuron).
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