---
title: "TUDCA vs Milk Thistle (Silymarin) Half-Life & Systemic Washout Calculator (2026 Pharmacokinetics) | Nutrition Research Labs"
source_url: "https://nutritionresearchlabs.com/half-life/tudca-vs-milk-thistle-silymarin-nac-liver-enzymes-audit"
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description: "Interactive TUDCA vs Milk Thistle (Silymarin) plasma half-life plotter (TUDCA: approx. 3 hours (circulates via enterohepatic recycling)). Calculate steady-state Cmax/Cmin accumulation, split-dose curves, and 5-half-life 97% washout dates."
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> **Canonical Source:** [https://nutritionresearchlabs.com/half-life/tudca-vs-milk-thistle-silymarin-nac-liver-enzymes-audit](https://nutritionresearchlabs.com/half-life/tudca-vs-milk-thistle-silymarin-nac-liver-enzymes-audit)
>
> *Interactive TUDCA vs Milk Thistle (Silymarin) plasma half-life plotter (TUDCA: approx. 3 hours (circulates via enterohepatic recycling)). Calculate steady-state Cmax/Cmin accumulation, split-dose curves, and 5-half-life 97% washout dates.*

## Elimination Kinetics & 97% Washout Benchmark for TUDCA vs Milk Thistle (Silymarin)

- **Documented Elimination Half-Life (T½):** TUDCA: approx. 3 hours (circulates via enterohepatic recycling)
- **Steady-State Equilibrium Window:** Achieved after 4.0 to 5.0 consecutive half-lives of regular administration.
- **97% Systemic Washout Threshold:** Requires 5.0x elimination half-lives following final dose administration.
- **Optimal Administration Schedule:** With meals, spaced away from oral medications by at least 2 hours

---

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