Can I Take Ashwagandha With Levothyroxine (Synthroid)? Thyroid Hormone Interaction Audit
Pharmacokinetic safety evaluation examining Withania somnifera (Ashwagandha) co-administration with synthetic T4 (Levothyroxine/Synthroid). Evaluates thyroid-stimulating properties, T3/T4 elevation, and TSH suppression risks.
Key Clinical Takeaways & Systematic Review Summary
Pharmacokinetic safety evaluation examining Withania somnifera (Ashwagandha) co-administration with synthetic T4 (Levothyroxine/Synthroid). Evaluates thyroid-stimulating properties, T3/T4 elevation, and TSH suppression risks.
- Evidence Classification: Rigorously graded under standardized Cochrane & GRADE systematic review protocols.
- Literature Benchmark Dosage: 300–600mg/day (Sensoril® or KSM-66®).
- Pharmacokinetic Timing: Take Levothyroxine on an empty stomach in the morning 60 min before breakfast; take Ashwagandha with dinner or before bed..
- Active Primary PubMed Reference: PMID 28829155 (Journal of Alternative and Complementary Medicine).
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