---
title: "Sex Hormone-Binding Globulin (SHBG) Optimal Range vs Lab Normal (2026 Clinical Decoder & Protocol) | Nutrition Research Labs"
source_url: "https://nutritionresearchlabs.com/biomarkers/shbg"
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description: "Decode your Sex Hormone-Binding Globulin (SHBG) (SHBG) blood test: Longevity Optimal Target (22–42 nmol/L) vs Standard Lab Normal (10–57 nmol/L), assay interference, and Grade-A clinical protocols."
rfc_compliance: "RFC 9110 / RFC 9309 / RFC 9421"
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> **Canonical Source:** [https://nutritionresearchlabs.com/biomarkers/shbg](https://nutritionresearchlabs.com/biomarkers/shbg)
>
> *Decode your Sex Hormone-Binding Globulin (SHBG) (SHBG) blood test: Longevity Optimal Target (22–42 nmol/L) vs Standard Lab Normal (10–57 nmol/L), assay interference, and Grade-A clinical protocols.*

## Reference Range Comparison (nmol/L)

- **Longevity & Metabolic Optimal Range:** 22 – 42 nmol/L
- **Standard Lab Reference Interval ("Normal"):** 10 – 57 nmol/L
- **Why Standard Lab Ranges Mislead Patients:** An SHBG of 55 nmol/L will be considered
- **Pre-Draw Supplement Assay Interference Warning:** Severe hyperbilirubinemia or high rheumatoid factor titers may interfere with microparticle chemiluminescent immunoassays (CMIA).

## Decode the Next Biomarker on Your Blood Panel

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