Clinical Trial Review: Standardized Ashwagandha (Withania somnifera) on Cortisol & Sleep Architecture
Double-blind, placebo-controlled trials confirm that standardized Withania somnifera root extract (KSM-66® / Sensoril®) reduces serum morning cortisol by 23% to 30.5%, with significant improvements in perceived stress scale (PSS) scores and sleep latency.
Key Clinical Takeaways & Systematic Review Summary
Double-blind, placebo-controlled trials confirm that standardized Withania somnifera root extract (KSM-66® / Sensoril®) reduces serum morning cortisol by 23% to 30.5%, with significant improvements in perceived stress scale (PSS) scores and sleep latency.
- Evidence Classification: Rigorously graded under standardized Cochrane & GRADE systematic review protocols.
- Literature Benchmark Dosage: 600 mg daily (divided into 300mg BID).
- Pharmacokinetic Timing: Administer with evening meal or 45 minutes prior to sleep..
- Active Primary PubMed Reference: PMID 23439798 (Indian Journal of Psychological Medicine).
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